Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3614-7. doi: 10.1016/j.bmcl.2006.01.102. Epub 2006 May 2.

Authors

Jon Bondebjerg¹, Henrik Fuglsang, Kirsten Rosendal Valeur, John Pedersen, Lars Naerum

Affiliation

¹ Arpida A/S, Vesterbrogade 188, DK-1800 Frederiksberg C, Denmark. jbondebjerg@arpida.uk

PMID: 16647256
DOI: 10.1016/j.bmcl.2006.01.102

Abstract

Using a dipeptide nitrile scaffold we have identified a potent and selective inhibitor of human dipeptidyl peptidase I.

MeSH terms

Cathepsin C / antagonists & inhibitors*
Dipeptides / chemical synthesis
Dipeptides / chemistry
Dipeptides / pharmacology*
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Humans
Molecular Structure
Nitriles / chemical synthesis
Nitriles / chemistry
Nitriles / pharmacology*
Stereoisomerism
Structure-Activity Relationship

Substances

Dipeptides
Enzyme Inhibitors
Nitriles
Cathepsin C